Endocrine Abstracts

Background: Aggressive prolactinomas are rare neoplasms that are characterized by rapid growth and usually large tumor size, invasion of adjacent structures, an aggressive clinical behavior with little response to conventional treatment, high rate of recurrence, and elevated morbidity and mortality.Case Report: 48-year-old woman diagnosed with life-threatening aggressive prolactinoma was referred to us for evaluation of complementary therapy after therap...

Introduction: Familial hypocalciuric hypercalcemia (FHH) is a rare condition (1–2% of causes for hypercalcemia) and may be confused with primary hyperparathyroidism. Diagnosis of FHH must be suspected in patients with a family history of chronic hypercalcemia, no symptoms and low urinary excretion. This disease is due to mutations in the calcium-sensing receptor (CASR) gene. Meningiomas are common intracranial tumors (15–20% of primary neoplasms of the central nervou...

Introduction: Although meningiomas often occurs in parasellar regions such as the tuberculum sellae, olfactory groove, and sphenoid wing, pure intrasellar meningiomas are extremely rare. Patients usually present with gradual visual deterioration secondary to compression of the optic apparatus. Obtaining a correct preoperative diagnosis will likely require a thorough clinical assessment including neuroimaging and endocrine studies.Case report: A 56 year-o...

Objectives: To evaluate the psychosocial aspects in a group of patients in follow-up in specific consultation of bariatric surgery prior to the intervention and in a group of patients intervened.Methods: Cross-sectional study of patients in follow-up in the specific morbid obesity consultation of the University Hospital Puerta del Mar (Cádiz) not intervened and a group intervened and in a group intervened, at 6–12 months of follow-up.<p cla...

Laser ablation of thyroid nodules has been used for the last two decads (Pacella et al, 2000). Surprisingly, complications are less frequent in patients treated without anesthesia, probably because eventual pain is an useful alarm symptom, leading the operator to repositioning the fiber during the procedure (Pacella et al., 2015).Material and methods: A total of 32 patients were included, without using local anesthesia. Nodules were solid, 5–72 ml v...

Introduction: MODY 5 is a rare type of dominantly inherited diabetes mellitus. It is asociated with mutations of the hepatocyte nuclear factor-1beta (HNF-1beta) gene. They are mostly missense mutations that produce truncated proteins with a variable clinical spectrum that encompasses among others: kidney, genital and pancreatic abnormalities.Case-report: A 35 years-old man without relevant medical history, presented with acute hypergycemia (541 mg/dl) an...

A 50-year-old woman with no history of interest who was admitted in hospital for progressive headache 2 weeks of evolution refractory to treatment that was accompanied by emetic syndrome and paresthesias in face and arms. A CT scan of the skull (urgency) was performed which was normal. Neurology improves with analgesia and steroids, presenting mild drowsiness and mild hyponatremia (121 mEq/l). A cerebral MRI was performed, showing a right subacute hemorrhagic adenoma of 1 cm t...

Ethanol and laser ablation of benign thyroid nodules is bursting rapidly in clinical practice because of its efficacy, safety and economy. However, these techniques require some manual operator training. In order to facilitate this hands-on training, we propose two homemade, cheap and specific simulators to practice these clinical procedures.Material and methodsTwo models were optimized: Gel-Phantom Coruna VR16 (gelatine a...

Introduction: Both insulin resistance and oxidative stress are implicated in the pathophysiology of various diseases such as type 2 diabetes mellitus, atherosclerosis or liver disease. Furthermore, the uncoupling protein-1 (UCP1) is involved in induced thermogenesis, related to the pathogenesis of obesity and diabetes. The aim of this study was to assess the impact of aerobic exercise on the inflammatory profile in patients with chronic hepatitis C.Metho...

Introduction: Surgery is the primary therapy in most acromelagic patients. When persistent disease is observed, adjuvant medical therapy is used. Pasireotide is a somatostatin analogue (SSA) not approved for acromegaly therapy yet, but with a potentially better response, given that it binds to four out of five somatostatin receptors.Materials and methods: We present the case of an acromegalic patient with resistance to many therapies and response to trea...